Nitrite and S -Nitrosohemoglobin Exchange Across the Human Cerebral and Femoral Circulation
نویسندگان
چکیده
منابع مشابه
Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans.
To determine the relative contributions of endothelial-derived nitric oxide (NO) vs. intravascular nitrogen oxide species in the regulation of human blood flow, we simultaneously measured forearm blood flow and arterial and venous levels of plasma nitrite, LMW-SNOs and HMW-SNOs, and red cell S-nitrosohemoglobin (SNO-Hb). Measurements were made at rest and during regional inhibition of NO synthe...
متن کاملCell-free and erythrocytic S-nitrosohemoglobin inhibits human platelet aggregation.
BACKGROUND Nitric oxide (NO) and related molecules are thought to inhibit human platelet aggregation by raising levels of cGMP. METHODS AND RESULTS Both oxidative stress (reactive oxygen species) and hemoglobin (Hb) seem to oppose NO effects. A major fraction of NO in the blood is bound to thiols of Hb, forming S-nitrosohemoglobin (SNO-Hb), which releases the NO group on deoxygenation in the ...
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ژورنال
عنوان ژورنال: Circulation
سال: 2017
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.116.024226